Frequently Asked Questions


Alka-Seltzer Original® provides fast relief for heartburn and acid indigestion with headache and body aches. Alka-Seltzer Plus® speeds relief from your tough symptoms for cold & flu, mucus & cough, or sinus & allergy.

Alka-Seltzer Plus® formulas are available in most drug stores, grocery stores, mass merchandisers, club stores and online. Or use our store locator to find another convenient location.

Alka-Seltzer Plus® no longer offers these products. To find a comparable product, call
1-800-986-0369 Monday-Friday, 9am-5pm EST to speak to a Consumer Relations Representative, or visit our product finder.


No. This ingredient was removed from Alka-Seltzer Plus® formulations in 2000.

Most of our products contain the nasal decongestant Phenylephrine Hydrochloride. Alka-Seltzer Plus-D is our only product that contains pseudoephedrine and can be found behind the pharmacy counter.

We don’t add gluten to our products. We can't guarantee they are 100% gluten free, as our products are produced in a facility that manufactures and packages items that may contain gluten.

This chart provides an easy reference to active ingredients in Alka-Seltzer Plus®.

Drug Purpose
Acetaminophen Pain Reliever/Fever Reducer
Aspirin Pain Reliever/Fever Reducer
Chlorpheniramine Maleate Antihistamine
Doxylamine Succinate Antihistamine
Diphenhydramine Hydrochloride Antihistamine/Cough Suppressant
Phenylephrine Bitartrate Nasal decongestant
Phenylephrine Hydrochloride Nasal decongestant
Pseudoephedrine Hydrochloride Nasal decongestant
Dextromethorphan Hydrobromide Cough Suppressant
Guaifenesin Expectorant

Not necessarily. Please be sure to read all labels carefully and follow directions as stated.

Dosing and Usage

Alka-Seltzer Plus® Night Cold is recommended for bedtime as it may cause marked drowsiness. If you’re home and able to rest, then it may be taken during the day.

Discontinue use and consult a physician if pain, cough, or nasal congestion gets worse or lasts longer than 7 days, or if fever gets worse or lasts longer than 3 days.

It dissolves best in water. Other liquids may contain ingredients which delay or affect dissolution. (For example, milk contains compounds such as protein and fat so it takes longer to dissolve the tablets.)

Room temperature is best. Cold water slows the dissolution, and warm water can make the product foam excessively. The surface of the tablet needs to be submerged completely in water for rapid dissolution.

The tablets may have started to break down. It's likely that the foil package has a slight imperfection or hole. This may cause the tablets to discolor and crumble. While there is no safety concern, be aware that the product won't be as effective.

We don't recommend using our products after they expire. It isn't harmful if ingested, but it may not be as effective in relieving your symptoms. We recommend you discard expired Alka-Seltzer Plus® products.

If you're pregnant or breast-feeding, contact your physician before using this product.

Liquid Gels: On the lower edge of the back carton, there are two down arrows. The flap lifts up to provide the remaining information, including the dosage directions. The information with the orange background (on the left) pertains to our Day Cold Formula, while the information with the green background (on the right) pertains to the Night Cold Formula. You can also view the directions online by visiting our product page.

Effervescent Tablets: The label on the back of the carton peels back, indicated by a yellow tab in the lower right corner. Once lifted, the remaining information and dosage directions are visible. The information with the orange background (on the left) pertains to our Day Cold Formula, while the information with the green background (on the right) pertains to the Night Cold Formula. View the directions online by visiting our product page.

A physician or pharmacist should always be consulted before taking more than one medication, as interactions between drugs are always possible.